Endocrine Abstracts

The enzyme dipeptidyl peptidase-IV (DPP-IV) is expressed by gut epithelial cells. DPP-IV cleaves X-proline dipeptides from the N-terminus of polypeptide hormones including GLP-1, GIP and PYY. DPP-IV causes a deactivation of the incretin hormones GLP-1 and GIP, whereas conversely, by converting PYY1–36 to PYY3–36 it allows specific activation of the Y2 receptors in the arcuate nucleus of the hypothalamus leading to hypophagia. Infused PYY3–36 has been ...

Background: Animal-derived protein consumption has been rising globally, driven by socioeconomic factors and shifts in dietary patterns to improve performance and support weight loss. In recent years an increasing trend has been observed for plant-based proteins due to sustainability concerns. Previous studies indicate that the metabolic effects of proteins may vary according to their origin. Thus, the aim of this single-blind, crossover study was to assess the acute effects o...

Annexin A1 (AnxA1), an endogenous glucocorticoid regulated protein, is a pivotal homeostatic regulator of the magnitude of the inflammatory response. We have previously demonstrated that plasma AnxA1 protein is significantly inversely correlated with waist to hip ratio (P=0.017). Given that low-level systemic inflammation is seen in metabolic syndrome-associated chronic pathologies, here, we investigate if AnxA1 is also involved in the regulation of adipose tissue infla...